High Ambiguity Driven biomolecular DOCKing
based on biochemical and/or biophysical information.
Version: 2.4 (January 2022) (changes)
Authors: Alexandre Bonvin and members of the computational structural biology group, Utrecht University
Bijvoet Center for Biomolecular Research
Padualaan 8, 3584 CH Utrecht, the Netherlands
Phone: +31-30-2533859 Fax: +31-30-2537623
HADDOCK is one of the flagship software in the EU H2020 BioExcel Center of Excellence for Biomolecular Research
HADDOCK2.4 manual: https://www.bonvinlab.org/software/haddock2.4/manual
HADDOCK2.4 webserver: https://wenmr.science.uu.nl/haddock2.4
Getting the software: license form
Questions about HADDOCK or looking for support? Ask BioExcel
HADDOCK best practice guide - A must read when starting to use our software!
An introduction to HADDOCK2.4: View the SBGrid [webinar]:
View recorded lecture
(https://www.youtube.com/watch?v=PDfFOUqdt5I) (June 29th, 2021).
Two lectures about integrative modelling and HADDOCK: Recording of a lecture by Prof. Bonvin at the 2021 BioExcel summerschool:
View recorded lecture Part I (46 min.)
View recorded lecture Part II (43 min.)
When using HADDOCK cite:
Cyril Dominguez, Rolf Boelens and Alexandre M.J.J. Bonvin. HADDOCK: a protein-protein docking approach based on biochemical and/or biophysical information.
J. Am. Chem. Soc. 125, 1731-1737 (2003).
G.C.P van Zundert, J.P.G.L.M. Rodrigues, M. Trellet, C. Schmitz, P.L. Kastritis, E. Karaca, A.S.J. Melquiond, M. van Dijk, S.J. de Vries and A.M.J.J. Bonvin. “The HADDOCK2.2 webserver: User-friendly integrative modeling of biomolecular complexes.”
J. Mol. Biol., 428, 720-725 (2016).
For additional citations when using specific modules see also our publication page.
HADDOCK is derived from ARIA scripts by Michael Nilges and Jens Linge.
- J.P. Linge, M. Habeck, W. Rieping and M. Nilges (2003). ARIA: automated NOE assignment and NMR structure calculation. Bioinformatics 19, 315-316.
The ongoing development of HADDOCK is the result of a team effort and in particular contributions from Cyril Dominguez, Aalt-Jan van Dijk, Sjoerd de Vries, Marc van Dijk, Ezgi Karaca, Panagiotis Kastritis, Adrien Melquiond, Mikael Trellet, Gydo van Zundert and Joao Rodrigues are acknowledged.
... more than fish or software..., discover the "capitaine" ...