HADDOCK

High Ambiguity Driven biomolecular DOCKing

based on biochemical and/or biophysical information.

Structure + Binformatic/Biophysical Data => Complex

Version: 2.4 (March 2024) (changes)

Authors: Alexandre Bonvin and members of the computational structural biology group, Utrecht University

Contact:

Bijvoet Center for Biomolecular Research
Padualaan 8, 3584 CH Utrecht, the Netherlands
Email: a.m.j.j.bonvin@uu.nl
Phone: +31-30-2533859 Fax: +31-30-2537623

HADDOCK is one of the flagship software in the EU H2020 BioExcel Center of Excellence for Biomolecular Research

HADDOCK2.4 manual: https://www.bonvinlab.org/software/haddock2.4/manual

HADDOCK2.4 webserver: https://wenmr.science.uu.nl/haddock2.4

Getting the software: license form

Questions about HADDOCK or looking for support? Ask BioExcel

HADDOCK best practice guide - A must read when starting to use our software!

An introduction to HADDOCK2.4: View the SBGrid [webinar]:

View recorded lecture

(https://www.youtube.com/watch?v=PDfFOUqdt5I) (June 29th, 2021).

Two lectures about integrative modelling and HADDOCK: Recording of a lecture by Prof. Bonvin at the 2021 BioExcel summerschool:

View recorded lecture Part I (46 min.)

View recorded lecture Part II (43 min.)

Publications:

When using HADDOCK cite:

Cyril Dominguez, Rolf Boelens and Alexandre M.J.J. Bonvin. HADDOCK: a protein-protein docking approach based on biochemical and/or biophysical information. J. Am. Chem. Soc. 125, 1731-1737 (2003).
R.V. Honorato, M.E. Trellet, B. Jiménez-García1, J.J. Schaarschmidt, M. Giulini, V. Reys, P.I. Koukos, J.P.G.L.M. Rodrigues, E. Karaca, G.C.P. van Zundert, J. Roel-Touris, C.W. van Noort, Z. Jandová, A.S.J. Melquiond and A.M.J.J. Bonvin. The HADDOCK2.4 web server: A leap forward in integrative modelling of biomolecular complexes. Nature Prot., Advanced Online Publication DOI: 10.1038/s41596-024-01011-0 (2024).

For additional citations when using specific modules see also our publication page.

Acknowledgments:

HADDOCK was originally derived from ARIA scripts by Michael Nilges and Jens Linge.

J.P. Linge, M. Habeck, W. Rieping and M. Nilges (2003). ARIA: automated NOE assignment and NMR structure calculation. Bioinformatics 19, 315-316.

The ongoing development of HADDOCK is the result of a team effort and in particular contributions from Cyril Dominguez, Aalt-Jan van Dijk, Sjoerd de Vries, Marc van Dijk, Ezgi Karaca, Panagiotis Kastritis, Adrien Melquiond, Mikael Trellet, Gydo van Zundert and Joao Rodrigues are acknowledged.

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